Article
The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK.
Antiviral therapy - 1 Jan 2012
Donegan Katherine L, Walker A Sarah, Dunn David, Judd Ali, Pillay Deenan, Menson Esse, Lyall Hermione, Tudor-Williams Gareth, Gibb Diana M
Abstract excerpt
BACKGROUND: We examined the prevalence of ritonavir-boosted darunavir (DRV) resistance-associated mutations (RAMs) in HIV-infected children in the UK to determine the drug's potential clinical utility as a first-line or second-line protease inhibitor (PI). METHODS: The prevalence of DRV RAMs, identified from IAS 2010 and Stanford, and the Stanford susceptibility score, were estimated in PI-naive and...
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