Article
G protein beta3 subunit polymorphism and risk of thrombosis and restenosis following coronary stent placement.
Atherosclerosis - 1 Mar 2000
von Beckerath N, Kastrati A, Koch W, Böttiger C, Mehilli J, Seyfarth M, Schömig A
Abstract excerpt
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction. On the cellular level, C825T polymorphism is associated with altered transmembrane signaling via adenylyl cyclase inhibiting (G(i)) G proteins. This study was designed to test whether C825T polymorphism has an impact on the processes leading to restenosis...
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