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An osteosarcoma zebrafish model implicates <i>Mmp‐19</i> and <i>Ets‐1</i> as well as reduced host immune response in angiogenesis and migration

2 Feb 2012

Abstract excerpt

About 40% of osteosarcoma patients die of metastases. Novel strategies to improve treatment of metastatic patients require a better understanding of the processes involved, like angiogenesis, migration, and the immune response. However, the rarity of osteosarcoma and its heterogeneity make this neoplasm difficult to study. Recently we reported malignant transformation of mouse mesenchymal stem cells (MSCs) which...

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PMID: 22297719
DOI: 10.1002/path.3998

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