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Article

MUTYH gene variants and breast cancer in a Dutch case–control study.

Breast cancer research and treatment - 1 Jul 2012

Out Astrid A, Wasielewski Marijke, Huijts Petra E A, van Minderhout Ivonne J H M, Houwing-Duistermaat Jeanine J, Tops Carli M J, Nielsen Maartje, Seynaeve Caroline, Wijnen Juul T, Breuning Martijn H, van Asperen Christi J, Schutte Mieke, Hes Frederik J, Devilee Peter

Abstract excerpt

The MUTYH gene is involved in base excision repair. MUTYH mutations predispose to recessively inherited colorectal polyposis and cancer. Here, we evaluate an association with breast cancer (BC), following up our previous finding of an elevated BC frequency among Dutch bi-allelic MUTYH mutation carriers. A case–control study was performed comparing 1,469 incident BC patients (ORIGO cohort), 471 individuals...

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Source

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Identifiers

PMID: 22297469
DOI: 10.1007/s10549-012-1965-0
PMCID: PMC3397219

Genes

MUTYH
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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