Article
Increased MUTYH mutation frequency among Dutch families with breast cancer and colorectal cancer.
Breast cancer research and treatment - 1 Dec 2010
Wasielewski Marijke, Out Astrid A, Vermeulen Joyce, Nielsen Maartje, van den Ouweland Ans, Tops Carli M J, Wijnen Juul T, Vasen Hans F A, Weiss Marjan M, Klijn Jan G M, Devilee Peter, Hes Frederik J, Schutte Mieke
Abstract excerpt
Homozygous and compound heterozygous MUTYH mutations predispose for MUTYH-associated polyposis (MAP). The clinical phenotype of MAP is characterised by the multiple colorectal adenomas and colorectal carcinoma. We previously found that female MAP patients may also have an increased risk for breast cancer. Yet, the involvement of MUTYH mutations in families with both breast cancer and colorectal cancer is unclear....
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