Article
[Some molecular-genetic markers, defining the pathogenesis of superficial and invasive bladder cancer].
Molekuliarnaia biologiia - 1 Jan 2000
Babaian A Iu, Kariakin O B, Teplov A A, Zaletaev D V, Nemtsova M V
Abstract excerpt
We have investigated deletions of 3p14, 9p21, 9q34, 17p13 (TP53) loci, activating FGFR3 mutations in exon 9 and aberrant methylation of RASSF1, RARbeta, P16, P14, CDH1 genes with the aim of the molecular pathogenesis pathways analysis of bladder cancer. FGFR3 activating mutations and 9p21 deletions were observed significantly more frequent in the group of non-invasive bladder cancer pTa than in minimally-invasive...
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