Article
Oral administration of the contact sensitizer trinitrochlorobenzene: initial sensitization and subsequent appearance of a suppressor population.
Cellular immunology - 1 Feb 1990
Gautam S C, Chikkala N F, Battisto J R
Abstract excerpt
Our earlier studies have demonstrated that intragastric administration of the hapten trinitrochlorobenzene (TNCB) 2 to 3 weeks prior to attempting sensitization with epidermally applied hapten can abrogate development of systemic contact sensitivity (CS). In this paper, we have examined whether onset of tolerance following intragastric administration of the hapten is preceded by development of hapten-specific CS....
Topics
- Administration, Cutaneous
- Administration, Oral
- Animals
- Antigens, Ly
- Cyclophosphamide
- Dermatitis, Contact
- Female
- Intestines
- Mice
- Mice, Inbred C3H
- Phenotype