Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Sm-like protein Hfq regulates polyadenylation dependent mRNA decay in Escherichia coli.

Molecular microbiology - 1 Nov 2004

Mohanty Bijoy K, Maples Valerie F, Kushner Sidney R

Abstract excerpt

In Escherichia coli, the post-transcriptional addition of poly(A) tails by poly(A) polymerase I (PAP I, pcnB) plays a significant role in cellular RNA metabolism. However, many important features of this system, including its regulation and the selection of polyadenylation sites, are still poorly understood. Here we show that the inactivation of Hfq (hfq), an abundant RNA-binding protein, leads to the reduction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoribonucleases
Share to Exoribonucleases
Share to Host Factor 1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polyadenylation

Share to Polynucleotide Adenylyltransferase

Share to Polyribonucleotide Nucleotidyltransferase

Share to rho GTP-Binding Proteins

Share to RNA Stability

Source

Identifiers

PMID: 15522076
DOI: 10.1111/j.1365-2958.2004.04337.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Sm-like protein Hfq regulates polyadenylation dependent mRNA decay in Escherichia coli.PMID 15522076Read ↗

Hfq affects the length and the frequency of short oligo(A) tails at the 3' end of Escherichia coli rpsO mRNAs.Semantic proximity Read ↗

Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death.Semantic proximity Read ↗

Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs.Semantic proximity Read ↗

Landscape of RNA polyadenylation in E. coli.Semantic proximity Read ↗

Hfq affects mRNA levels independently of degradation.Semantic proximity Read ↗

The functional Hfq-binding module of bacterial sRNAs consists of a double or single hairpin preceded by a U-rich sequence and followed by a 3' poly(U) tail.Semantic proximity Read ↗

Two seemingly homologous noncoding RNAs act hierarchically to activate glmS mRNA translation.Semantic proximity Read ↗

Polyadenylation helps regulate functional tRNA levels in Escherichia coli.Semantic proximity Read ↗

Deep sequencing of Salmonella RNA associated with heterologous Hfq proteins in vivo reveals small RNAs as a major target class and identifies RNA processing phenotypes.Semantic proximity Read ↗

Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation.Semantic proximity Read ↗

Sm-like protein Hfq: location of the ATP-binding site and the effect of ATP on Hfq-- RNA complexes.Semantic proximity Read ↗

Major role for mRNA binding and restructuring in sRNA recruitment by Hfq.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.