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Article

Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy

27 Jan 2012

Abstract excerpt

Among oncolytic viruses, the vesicular stomatitis virus (VSV) is especially potent and a highly promising agent for the treatment of cancer. But, even though effective against multiple tumor entities in preclinical animal models, replication-competent VSV exhibits inherent neurovirulence, which has so far hindered clinical development. To overcome this limitation, replication-defective VSV vectors for cancer gene...

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PMID: 22286341
DOI: 10.1007/s00109-012-0863-6

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