Article
Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells.
Journal of virology - 1 Feb 2010
Wollmann Guido, Rogulin Vitaliy, Simon Ian, Rose John K, van den Pol Anthony N
Abstract excerpt
Vesicular stomatitis virus (VSV) has been shown in laboratory studies to be effective against a variety of tumors, including malignant brain tumors. However, attenuation of VSV may be necessary to balance the potential toxicity toward normal cells, particularly when targeting brain tumors. Here w...
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