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Article

Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells.

Journal of virology - 1 Feb 2010

Wollmann Guido, Rogulin Vitaliy, Simon Ian, Rose John K, van den Pol Anthony N

Abstract excerpt

Vesicular stomatitis virus (VSV) has been shown in laboratory studies to be effective against a variety of tumors, including malignant brain tumors. However, attenuation of VSV may be necessary to balance the potential toxicity toward normal cells, particularly when targeting brain tumors. Here we compared 10 recombinant VSV variants resulting from different attenuation strategies. Attenuations included gene...

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Identifiers

PMID: 19906910
DOI: 10.1128/JVI.02040-09
PMCID: PMC2812324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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