Article
ABC transporters and their role in nucleoside and nucleotide drug resistance.
Biochemical pharmacology - 15 Apr 2012
Fukuda Yu, Schuetz John D
Abstract excerpt
ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based drugs. While nucleoside based drugs have been used for many years in the treatment of solid and hematological malignancies as well as viral and autoimmune diseases, the potential contribution of ABC transporters has only recently been recognized. This neglect is...
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