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Article

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis.

BMC medical genetics - 27 Jan 2012

Knüppel Sven, Esparza-Gordillo Jorge, Marenholz Ingo, Holzhütter Hermann-Georg, Bauerfeind Anja, Ruether Andreas, Weidinger Stephan, Lee Young-Ae, Rohde Klaus

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) provide an increasing number of single nucleotide polymorphisms (SNPs) associated with diseases. Our aim is to exploit those closely spaced SNPs in candidate regions for a deeper analysis of association beyond single SNP analysis, combining the classical stepwise regression approach with haplotype analysis to identify risk haplotypes for complex diseases....

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PMID: 22284537
DOI: 10.1186/1471-2350-13-8
PMCID: PMC3398269

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