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A genome-wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis.

Contact dermatitis - 1 Sept 2024

Rosenberg Fieke M, van der Most Peter J, Loman Laura, Kamali Zoha, Dittmar Daan, Snieder Harold, Schuttelaar Marie L A

Abstract excerpt

BACKGROUND: Twin studies revealed that genetic effects play a role in hand eczema (HE), but the responsible genetic factors are unknown. OBJECTIVES: To identify and characterise genetic loci associated with HE and to provide insight into the genetic overlap between HE and atopic dermatitis (AD). METHODS: We used questionnaire-derived and genotype data from the European population-based Lifelines cohort and...

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PMID: 38924601
DOI: 10.1111/cod.14619

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