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Article

eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.

Journal of the American Society of Nephrology : JASN - 1 Apr 2012

Li Feng, Hagaman John R, Kim Hyung-Suk, Maeda Nobuyo, Jennette J Charles, Faber James E, Karumanchi S Ananth, Smithies Oliver, Takahashi Nobuyuki

Abstract excerpt

Excess soluble fms-like tyrosine kinase 1 (sFlt-1) of vascular endothelial growth factor receptor 1 secreted from the placenta causes pre-eclampsia-like features by antagonizing vascular endothelial growth factor signaling, which can lead to reduced endothelial nitric oxide synthase (eNOS) activity; the effect of this concomitant decrease in eNOS activity is unknown. We tested whether the decrease in nitric oxide...

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Identifiers

PMID: 22282588
DOI: 10.1681/ASN.2011040369
PMCID: PMC3312503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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