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Article

Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein.

European journal of medical research - 31 Dec 2024

Wei Yingying, Tian Haojun, Wei Xuancheng, Zhang Ai, Wei Mengtian, Wang Ruixue, Zhang Lu, Qiao Ping, Wang Kai

Abstract excerpt

BACKGROUND: Preeclampsia (PE) is a pregnancy-specific, multisystemic disorder that affects 2-8% pregnancies worldwide and is a leading cause of maternal and perinatal mortality. At present, there is no cure for PE apart from delivery the placenta. Therefore, it is important and urgent to possess a suitable animal model to study the pathology and treatment of PE. When exogenous soluble fms-like tyrosine kinase-1...

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Identifiers

PMID: 39741314
DOI: 10.1186/s40001-024-02223-6
PMCID: PMC11689622

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