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Article

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

27 Dec 2010

Abstract excerpt

Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in...

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PMID: 21187414
DOI: 10.1073/pnas.1011293108

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