Article
Essentiality and damage in metabolic networks.
Bioinformatics (Oxford, England) - 1 Jan 2004
Lemke Ney, Herédia Fabiana, Barcellos Cláudia K, Dos Reis Adriana N, Mombach José C M
Abstract excerpt
Understanding the architecture of physiological functions from annotated genome sequences is a major task for postgenomic biology. From the annotated genome sequence of the microbe Escherichia coli, we propose a general quantitative definition of enzyme importance in a metabolic network. Using a graph analysis of its metabolism, we relate the extent of the topological damage generated in the metabolic network by...
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