Inhibition of amyloid precursor protein beta-secretase cleavage site affects survival and motor functions of amyotrophic lateral sclerosis transgenic mice.

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease defined by motor neuron loss. Recent studies have reported an increase in amyloid precursor protein (APP) levels and in its cleavage products in ALS patients indicating their possible involvement in this disease. APP is a transmembrane protein processed either by β-secretase or α-secretase followed by γ-secretase. The APP...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid beta-Protein Precursor
• Share to Amyloid Precursor Protein Secretases