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Article

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

Human molecular genetics - 1 Nov 2012

Rodrigues Elizabeth M, Weissmiller April M, Goldstein Lawrence S B

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by amyloid plaques and neurofibrillary tangles in the brain. Before these hallmark features appear, signs of axonal transport defects develop, though the initiating events are not clear. Enhanced amyloidogenic processing of amyloid precursor protein (APP) plays an integral role in AD pathogenesis, and previous work suggests that...

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Source

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Identifiers

PMID: 22843498
DOI: 10.1093/hmg/dds297
PMCID: PMC3471392

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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