Article
The Structure‐Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious
21 Feb 2011
Abstract excerpt
The p53 protein is the cell's principal bastion of defense against tumor-associated DNA damage. Commonly referred as a "guardian of the genome", p53 is responsible for determining the fate of the cell when the integrity of its genome is damaged. The development of tumors requires breaching this defense line. All known tumor cells either mutate the p53 gene, or in a similar number of cases, use internal cell p53...
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