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Article

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

5 Jan 2004

Abstract excerpt

MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability. Overexpression of MDM2, found in many human tumors, effectively impairs p53 function. Inhibition of MDM2-p53 interaction can stabilize p53 and may offer a novel strategy for cancer therapy. Here, we identify potent and selective small-molecule antagonists of MDM2 and confirm their...

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PMID: 14704432
DOI: 10.1126/science.1092472

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