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Article

Perlecan-deficient mutation impairs corneal epithelial structure.

Investigative ophthalmology & visual science - 9 Mar 2012

Inomata Takenori, Ebihara Nobuyuki, Funaki Toshinari, Matsuda Akira, Watanabe Yasuo, Ning Liang, Xu Zhuo, Murakami Akira, Arikawa-Hirasawa Eri

Abstract excerpt

PURPOSE: To elucidate the role of perlecan (Hspg2), a large multidomain heparan sulfate proteoglycan expressed in the basement membrane, in the structure of the corneal epithelium. METHODS: A previously developed perlecan-deficient (Hspg2⁻/⁻-Tg) mouse model was used. Histologic analysis of their corneas was performed by light and transmission electron microscopy. The localization of perlecan in the corneas of...

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Identifiers

PMID: 22266517
DOI: 10.1167/iovs.11-8742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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