Article
Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models.
Investigative ophthalmology & visual science - 3 Jun 2024
Akoto Theresa, Hadvina Rachel, Jones Skyler, Cai Jingwen, Yu Hongfang, McCord Hayden, Jin Charles X J, Estes Amy J, Gan Lin, Kuo Anthony, Smith Sylvia B, Liu Yutao
Abstract excerpt
Purpose: It is necessary to establish a mouse model of keratoconus (KC) for research and therapy. We aimed to determine corneal phenotypes in 3 Ppip5k2 mouse models. Methods: Central corneal thickness (CCT) was determined using spectral domain optical coherence tomography (SD-OCT) in Ppip5k2+/K^ (n = 41 eyes), Ppip5k2K^/K^ (n = 17 eyes) and 2 knock-in mice, Ppip5k2S419A/+ (n = 54 eyes) and Ppip5k2S419A/S419A (n =...
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