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Article

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection.

BMC cancer - 24 Apr 2013

Zapparoli Giada V, Jorissen Robert N, Hewitt Chelsee A, McBean Michelle, Westerman David A, Dobrovic Alexander

Abstract excerpt

BACKGROUND: The JAK2 V617F mutation is the most frequent somatic change in myeloproliferative neoplasms, making it an important tumour-specific marker for diagnostic purposes and for the detection of minimal residual disease. Sensitive quantitative assays are required for both applications, particularly for the monitoring of minimal residual disease, which requires not only high sensitivity but also very high...

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PMID: 23617802
DOI: 10.1186/1471-2407-13-206
PMCID: PMC3658971

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JAK2

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