On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies.

Abstract excerpt

For the meta-analysis of genome-wide association studies, we propose a new method to adjust for the population stratification and a linear mixed approach that combines family-based and unrelated samples. The proposed approach achieves similar power levels as a standard meta-analysis which combines the different test statistics or p values across studies. However, by virtue of its design, the proposed approach is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Alzheimer Disease