Article
On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls.
American journal of human genetics - 9 Apr 2010
Lasky-Su Jessica, Won Sungho, Mick Eric, Anney Richard J L, Franke Barbara, Neale Benjamin, Biederman Joseph, Smalley Susan L, Loo Sandra K, Todorov Alexandre, Faraone Stephen V, Weiss Scott T, Lange Christoph
Abstract excerpt
Large numbers of control individuals with genome-wide genotype data are now available through various databases. These controls are regularly used in case-control genome-wide association studies (GWAS) to increase the statistical power. Controls are often "unselected" for the disease of interest and are not matched to cases in terms of confounding factors, making the studies more vulnerable to confounding as a...
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