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Article

β2-Glycoprotein I and Protection from Anti-SSA/Ro60–Associated Cardiac Manifestations of Neonatal Lupus

20 May 2011

Abstract excerpt

One mechanism to molecularly explain the strong association of maternal anti-Ro60 Abs with cardiac disease in neonatal lupus (NL) is that these Abs initiate injury by binding to apoptotic cardiomyocytes in the fetal heart. Previous studies have demonstrated that β(2)-glycoprotein I (β(2)GPI) interacts with Ro60 on the surface of apoptotic Jurkat cells and prevents binding of anti-Ro60 IgG. Accordingly, the...

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PMID: 21602492
DOI: 10.4049/jimmunol.1100122

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