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Article

Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Mar 2012

Martínez-Barricarte Rubén, Recalde Sergio, Fernández-Robredo Patricia, Millán Isabel, Olavarrieta Leticia, Viñuela Antonio, Pérez-Pérez Julián, García-Layana Alfredo, Rodríguez de Córdoba Santiago

Abstract excerpt

PURPOSE: Age-related macular degeneration (AMD) has a strong genetic component with a major locus at 1q31, including the complement factor H (CFH) gene. Detailed analyses of this locus have demonstrated the existence of one SNP haplotype block, carrying the CFH 402His allele, which confers increased risk for AMD, and two protective SNP haplotypes, one of them carrying a deletion of the CFHR1 and CFHR3 genes...

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Share to Chromosomes, Human, Pair 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22247456
DOI: 10.1167/iovs.11-8709

Genes

CFHR1
CFH
CFHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration.PMID 22247456Read ↗

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