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Article

Establishing the epigenetic status of the Prader–Willi/Angelman imprinting center in the gametes and embryo

14 Sept 2004

Abstract excerpt

The Prader-Willi/Angelman imprinted domain on human chromosome 15q11-q13 is regulated by an imprinting control center (IC) composed of a sequence around the SNRPN promoter (PWS-SRO) and a sequence located 35 kb upstream (AS-SRO). We have previously hypothesized that the primary imprint is established on AS-SRO, which then confers imprinting on PWS-SRO. Here we examine this hypothesis using a transgene that...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 15367489
DOI: 10.1093/hmg/ddh290

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