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Article

Variation in the uncoupling protein 2 and 3 genes and human performance.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2012

Dhamrait Sukhbir S, Williams Alun G, Day Stephen H, Skipworth James, Payne John R, World Michael, Humphries Steve E, Montgomery Hugh E

Abstract excerpt

Uncoupling proteins 2 and 3 (UCP2 and UCP3) may negatively regulate mitochondrial ATP synthesis and, through this, influence human physical performance. However, human data relating to both these issues remain sparse. Examining the association of common variants in the UCP3/2 locus with performance phenotypes offers one means of investigation. The efficiency of skeletal muscle contraction, delta efficiency (DE),...

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Identifiers

PMID: 22241057
DOI: 10.1152/japplphysiol.00766.2011
PMCID: PMC3330832

Genes

UCP2
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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