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Article

Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer.

British journal of cancer - 14 Feb 2012

Dotan E, Meropol N J, Zhu F, Zambito F, Bove B, Cai K Q, Godwin A K, Golemis E A, Astsaturov I, Cohen S J

Abstract excerpt

BACKGROUND: Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome. We correlated increased AURKA-CN in mCRC tumours with KRAS mutation status, overall and progression-free survival (OS, PFS). METHODS: Sixty-one mCRC tumours were analysed for AURKA-CN using q-PCR, and KRAS mutation status by direct sequencing....

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Source

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Identifiers

PMID: 22240781
DOI: 10.1038/bjc.2011.587
PMCID: PMC3322945

Genes

AURKA
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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