Mycobacterium tuberculosis Promotes Regulatory T-Cell Expansion via Induction of Programmed Death-1 Ligand 1 (PD-L1, CD274) on Dendritic Cells

Abstract excerpt

TO THE EDITOR—CD4+CD25+FoxP3+ regulatory T cells (Tregs) are critical for the maintenance of immune tolerance by suppressing immune cell functions. In the context of infection such as Mycobacterium tuberculosis, Tregs can also suppress efficient protective immune responses against the pathogen and its effective clearance [1]. Results from studies of patients with tuberculosis and experimental models have shown...

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