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Article

Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process.

European journal of human genetics : EJHG - 1 Jun 2012

Kuot Abraham, Hewitt Alex W, Griggs Kim, Klebe Sonja, Mills Richard, Jhanji Vishal, Craig Jamie E, Sharma Shiwani, Burdon Kathryn P

Abstract excerpt

Fuchs' endothelial dystrophy (FED) is a disease affecting the corneal endothelium. Recent studies reported significant association of polymorphisms in the TCF4 (transcription factor 4) gene, and a borderline association of PTPRG (protein tyrosine phosphatase, receptor type, G) variants with late-onset FED in Caucasians from the United States. Association of TCF4 has also been reported in the Chinese population....

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Source

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Identifiers

PMID: 22234156
DOI: 10.1038/ejhg.2011.248
PMCID: PMC3355250

Genes

CLU
TGFBI
TCF4
PTPRG
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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