Article
Pulmonary adenocarcinoma in situ: analyses of a large series with reference to smoking, driver mutations, and receptor tyrosine kinase pathway activation.
The American journal of surgical pathology - 1 Jul 2015
Sato Seijiro, Motoi Noriko, Hiramatsu Miyako, Miyauchi Eisaku, Ono Hiroshi, Saito Yuichi, Nagano Hiroko, Ninomiya Hironori, Inamura Kentaro, Uehara Hirofumi, Mun Mingyon, Sakao Yukinori, Okumura Sakae, Tsuchida Masanori, Ishikawa Yuichi
Abstract excerpt
Lung adenocarcinomas in situ (AISs) often occur in individuals who have never smoked, although smoking is one of the main causes of lung cancer. To characterize AIS and, in particular, determine how AIS might be related to smoking, we collected a large number of AIS cases and examined clinicopathologic features, EGFR and KRAS mutation status, and activation status of receptor tyrosine kinase downstream signal...
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