Article
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Cell metabolism - 4 Jan 2012
Ahlqvist Kati J, Hämäläinen Riikka H, Yatsuga Shuichi, Uutela Marko, Terzioglu Mügen, Götz Alexandra, Forsström Saara, Salven Petri, Angers-Loustau Alexandre, Kopra Outi H, Tyynismaa Henna, Larsson Nils-Göran, Wartiovaara Kirmo, Prolla Tomas, Trifunovic Aleksandra, Suomalainen Anu
Abstract excerpt
Somatic stem cell (SSC) dysfunction is typical for different progeroid phenotypes in mice with genomic DNA repair defects. MtDNA mutagenesis in mice with defective Polg exonuclease activity also leads to progeroid symptoms, by an unknown mechanism. We found that Polg-Mutator mice had neural (NSC) and hematopoietic progenitor (HPC) dysfunction already from embryogenesis. NSC self-renewal was decreased in vitro,...
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