Article
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.
Nature communications - 3 Jan 2012
Lavasani Mitra, Robinson Andria R, Lu Aiping, Song Minjung, Feduska Joseph M, Ahani Bahar, Tilstra Jeremy S, Feldman Chelsea H, Robbins Paul D, Niedernhofer Laura J, Huard Johnny
Abstract excerpt
With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated...
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