Article
Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors as defined by high-density single-nucleotide polymorphism arrays.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2012
Muñoz-Bellvis Luís, Fontanillo Celia, González-González María, Garcia Eva, Iglesias Manuel, Esteban Carmen, Gutierrez M L, Abad M M, Bengoechea Oscar, De Las Rivas Javier, Orfao Alberto, Sayagués J M
Abstract excerpt
Most genetic studies in colorectal carcinomas have focused on those abnormalities that are acquired by primary tumors, particularly in the transition from adenoma to carcinoma, whereas few studies have compared the genetic abnormalities of primary versus paired metastatic samples. In this study, we used high-density 500K single-nucleotide polymorphism arrays to map the overall genetic changes present in liver...
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