Article
Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes.
The Journal of steroid biochemistry and molecular biology - 1 Dec 1992
White P C, Pascoe L, Curnow K M, Tannin G, Rösler A
Abstract excerpt
There are two steroid 11β-hydroxylase isozymes encoded by the CYP11B1 and CYP11B2 genes on human chromosome 8q. The first is expressed at high levels in the normal adrenal gland, has 11β-hydroxylase activity and is regulated by ACTH. Mutations in the corresponding gene cause congenital adrenal hyperplasia due to 11β-hydroxylase deficiency; thus, this isozyme is required for cortisol biosynthesis. The second...
Topics
- 11-beta-Hydroxysteroid Dehydrogenases
- Adrenal Glands
- Adrenal Hyperplasia, Congenital
- Aldosterone
- Animals
- Cytochrome P-450 CYP11B2
- Gene Expression Regulation, Enzymologic
- Humans
- Hydrocortisone
- Hyperaldosteronism