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Article

Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.

Hormone research - 1 Jan 1999

Peter M, Dubuis J M, Sippell W G

Abstract excerpt

The most potent corticosteroids are 11beta-hydroxylated compounds. In humans, two cytochrome P450 isoenzymes with 11beta-hydroxylase activity, catalysing the biosynthesis of cortisol and aldosterone, are present in the adrenal cortex. CYP11B1, the gene encoding 11beta-hydroxylase (P450c11), is expressed on high levels in the zona fasciculata and is regulated by ACTH. CYP11B2, the gene encoding aldosterone...

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Identifiers

PMID: 10559665
DOI: 10.1159/000023374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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