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Article

Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.

Seminars in reproductive medicine - 1 Aug 2002

Peter Michael

Abstract excerpt

The most potent corticosteroids are 11beta-hydroxylated compounds. In humans, two cytochrome P450 isoenzymes with 11beta-hydroxylase activity, catalyzing the biosynthesis of cortisol and aldosterone, are present in the adrenal cortex. CYP11B1, the gene encoding 11beta-hydroxylase (P450c11), is expressed in high levels in the zona fasciculata and is regulated by adrenocorticotropic hormone (ACTH). CYP11B2, the...

Topics

Adrenal Hyperplasia, Congenital
Aldosterone
Humans
Hydrocortisone
Mutation
Prenatal Care
Prenatal Diagnosis
Steroid 11-beta-Hydroxylase

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12428205
DOI: 10.1055/s-2002-35389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12428205-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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