Article
Disorders of steroid 11 beta-hydroxylase isozymes.
Endocrine reviews - 1 Aug 1994
White P C, Curnow K M, Pascoe L
Abstract excerpt
The most active corticosteroids are 11 beta-hydroxylated. Humans have two isozymes with 11 beta-hydroxylase activity that are respectively required for cortisol and aldosterone synthesis. CYP11B1 (11 beta-hydroxylase) is expressed at high levels and is regulated by ACTH, whereas CYP11B2 (aldosterone synthase) is normally expressed at low levels and is regulated by angiotensin II. In addition to 11...
Topics
- Adrenal Cortex
- Adrenal Hyperplasia, Congenital
- Aldosterone
- Cytochrome P-450 CYP11B2
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Hydrocortisone
- Hyperaldosteronism
- Isoenzymes
- Male
- Mutation