New Mutations at the Imprinted <i>Gnas</i> Cluster Show Gene Dosage Effects of Gs <i>α</i> in Postnatal Growth and Implicate XL <i>α</i> s in Bone and Fat Metabolism but Not in Suckling

Abstract excerpt

The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been established. In this study, we have generated two new mutants (Ex1A-T-CON and Ex1A-T) at the Gnas cluster. Paternal inheritance of Ex1A-T-CON leads to loss of...

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