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Article

The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.

Nature genetics - 1 Aug 2004

Plagge Antonius, Gordon Emma, Dean Wendy, Boiani Romina, Cinti Saverio, Peters Jo, Kelsey Gavin

Abstract excerpt

Genomic imprinting, by which maternal and paternal alleles of some genes have different levels of activity, has profound effects on growth and development of the mammalian fetus. The action of imprinted genes after birth, in particular while the infant is dependent on maternal provision of nutrients, is far less well understood. We disrupted a paternally expressed transcript at the Gnas locus, Gnasxl, which...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15273686
DOI: 10.1038/ng1397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.PMID 15273686Read ↗

The Alternative Stimulatory G Protein α-Subunit XLαs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult MiceSemantic proximity Read ↗

Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Semantic proximity Read ↗

Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Semantic proximity Read ↗

New Mutations at the Imprinted <i>Gnas</i> Cluster Show Gene Dosage Effects of Gs <i>α</i> in Postnatal Growth and Implicate XL <i>α</i> s in Bone and Fat Metabolism but Not in SucklingSemantic proximity Read ↗

Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse.Semantic proximity Read ↗

The role of GNAS and other imprinted genes in the development of obesity.Semantic proximity Read ↗

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.Semantic proximity Read ↗

Role of G(s)α in central regulation of energy and glucose metabolism.Semantic proximity Read ↗

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Physiological dysfunctions associated with mutations of the imprinted Gnas locus.Semantic proximity Read ↗

Relative functions of Gαs and its extra-large variant XLαs in the endocrine system.Semantic proximity Read ↗

Imprinting status of Galpha(s), NESP55, and XLalphas in cell cultures derived from human embryonic germ cells: GNAS imprinting in human embryonic germ cells.Semantic proximity Read ↗

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