Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

2 Jan 2012

Abstract excerpt

Disruption of skeletal muscle homeostasis by substitution with fibrotic tissue constitutes the principal cause of death in Duchenne muscular dystrophy (DMD) patients, yet the implicated fibrogenic mechanisms remain poorly understood. This study identifies the extracellular PAI-1/urokinase-type plasminogen activator (uPA) balance as an important regulator of microribonucleic acid (miR)-21 biogenesis, controlling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22213800
DOI: 10.1083/jcb.201105013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophyPMID 22213800Read ↗

Microrna-21: A Central Regulator of Fibrotic Diseases Via Various TargetsSemantic proximity Read ↗

Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy.Semantic proximity Read ↗

PAI-1, the Plasminogen System, and Skeletal MuscleSemantic proximity Read ↗

MicroRNA expression profile of fibro-adipogenic progenitors in Duchenne muscular dystrophy reveals dysregulation of adipogenesis-related microRNAsSemantic proximity Read ↗

Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophySemantic proximity Read ↗

The FibromiR miR-214-3p Is Upregulated in Duchenne Muscular Dystrophy and Promotes Differentiation of Human Fibro-Adipogenic Muscle ProgenitorsSemantic proximity Read ↗

Overactive PDGFRα and PDGFRβ promote distinct yet overlapping phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving drastic muscle growthSemantic proximity Read ↗

MicroRNA-21-5p as a novel therapeutic target for osteoarthritisSemantic proximity Read ↗

PAI-1: A New Target for Controlling Lung-Cell Senescence and Fibrosis?Semantic proximity Read ↗

Regulation of Fibroblast Activation Protein-α Expression: Focus on Intracellular Protein InteractionsSemantic proximity Read ↗

MiR-26a modulates extracellular matrix homeostasis in cartilageSemantic proximity Read ↗

SMAD proteins control DROSHA-mediated microRNA maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.