Article
The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers.
Breast cancer research and treatment - 1 Apr 2012
Laitman Yael, Kuchenbaecker Karoline B, Rantala Johanna, Hogervorst Frans, Peock Susan, Godwin Andrew K, Arason Adalgeir, Kirchhoff Tomas, Offit Kenneth, Isaacs Claudine, Schmutzler Rita K, Wappenschmidt Barbara, Nevanlinna Heli, Chen Xiaoqing, Chenevix-Trench Georgia, Healey Sue, Couch Fergus, Peterlongo Paolo, Radice Paolo, Nathanson Katherine L, Caligo Maria Adelaide, Neuhausen Susan L, Ganz Patricia, Sinilnikova Olga M, McGuffog Lesley, Easton Douglas F, Antoniou Antonis C, Wolf Ido, Friedman Eitan
Abstract excerpt
Klotho (KL) is a putative tumor suppressor gene in breast and pancreatic cancers located at chromosome 13q12. A functional sequence variant of Klotho (KL-VS) was previously reported to modify breast cancer risk in Jewish BRCA1 mutation carriers. The effect of this variant on breast and ovarian cancer risks in non-Jewish BRCA1/BRCA2 mutation carriers has not been reported. The KL-VS variant was genotyped in women...
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