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Cancer risk in Jewish BRCA1 and BRCA2 mutation carriers: effects of oral contraceptive use and parental origin of mutation.

Breast cancer research and treatment - 1 Sept 2011

Bernholtz Shiri, Laitman Yael, Kaufman Bella, Paluch Shimon Shani, Friedman Eitan

Abstract excerpt

BRCA1 and BRCA2 germline mutations substantially increase breast and ovarian cancer risk, yet penetrance is incomplete. The effects of oral contraceptives (OC) on breast cancer risk in mutation carriers are unclear, and the putative effect of parental origin of mutation on cancer risk has not been reported. Data on OC use and parental origin of the mutation were obtained at counseling from 888 BRCA1 (n = 638) or...

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Identifiers

PMID: 21499684
DOI: 10.1007/s10549-011-1509-z

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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