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Article

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.

Circulation research - 4 Mar 2005

Arking Dan E, Atzmon Gil, Arking Albert, Barzilai Nir, Dietz Harry C

Abstract excerpt

We previously identified a functional variant of KLOTHO, termed KL-VS, that is associated with human aging and early-onset occult coronary artery disease. Here, we determine whether the KL-VS allele influences cardiovascular disease risk factors, cardiovascular events, and ultimately, mortality. A total of 525 Ashkenazi Jews composed of 216 probands (age > or =95 years) and 309 unrelated individuals (ages 51 to...

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Identifiers

PMID: 15677572
DOI: 10.1161/01.RES.0000157171.04054.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.PMID 15677572Read ↗

KLOTHO allele status and the risk of early-onset occult coronary artery disease.Semantic proximity Read ↗

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect.Semantic proximity Read ↗

Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke.Semantic proximity Read ↗

Klotho KL-VS genotype is involved in blood pressure regulation.Semantic proximity Read ↗

Association of human aging with a functional variant of klotho.Semantic proximity Read ↗

Absence of kl-vs variant of klotho gene in Iranian cardiac patients (comparison to the world populations).Semantic proximity Read ↗

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.Semantic proximity Read ↗

Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism.Semantic proximity Read ↗

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.Semantic proximity Read ↗

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Longevity Klotho gene polymorphism and the risk of dementia in older men.Semantic proximity Read ↗

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