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Article

FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.

Circulation research - 17 Feb 2012

Zhang Jue, Liu Junchen, Huang Yanqing, Chang Julia Y F, Liu Leyuan, McKeehan Wallace L, Martin James F, Wang Fen

Abstract excerpt

RATIONALE: Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. OBJECTIVE: To investigate the mechanism by which FGF signaling regulates cardiac progenitor cell differentiation. METHODS AND RESULTS: Using mice with tissue-specific ablation of FGF receptors and FGF receptor...

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Identifiers

PMID: 22207710
DOI: 10.1161/CIRCRESAHA.111.255950
PMCID: PMC3677753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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