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Article

A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D.

Cancer research - 15 Feb 2012

Ting Huei-Ju, Yasmin-Karim Sayeda, Yan Shian-Jang, Hsu Jong-Wei, Lin Tzu-Hua, Zeng Weisi, Messing James, Sheu Tzong-Jeng, Bao Bo-Ying, Li Willis X, Messing Edward, Lee Yi-Fen

Abstract excerpt

Both epidemiologic and laboratory studies have shown the chemopreventive effects of 1α,25-dihydroxyvitamin D(3) (1,25-VD) in tumorigenesis. However, understanding of the molecular mechanism by which 1,25-VD prevents tumorigenesis remains incomplete. In this study, we used an established mouse model of chemical carcinogenesis to investigate how 1,25-VD prevents malignant transformation. In this model, 1,25-VD...

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Source

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Identifiers

PMID: 22207345
DOI: 10.1158/0008-5472.CAN-11-0042
PMCID: PMC6616526

Genes

ATM
VDR
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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