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Article

RB1 mutations and second primary malignancies after hereditary retinoblastoma.

Familial cancer - 1 Jun 2012

Dommering Charlotte J, Marees Tamara, van der Hout Annemarie H, Imhof Saskia M, Meijers-Heijboer Hanne, Ringens Peter J, van Leeuwen Flora E, Moll Annette C

Abstract excerpt

Survivors of hereditary retinoblastoma have a high risk of second primary malignancies, but it has not been investigated whether specific RB1 germline mutations are associated with greater risk of second primary malignancies in a large cohort. We conducted a retrospective cohort study of 199 survivors of hereditary retinoblastoma with a documented RB1 germline mutation diagnosed between 1905 and 2005. In total,...

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Identifiers

PMID: 22205104
DOI: 10.1007/s10689-011-9505-3
PMCID: PMC3365233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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